The Greco-Bactrian Kingdom was founded when Diodotus I, the satrap of Bactria (and probably the surrounding provinces) seceded from the Seleucid Empire around 250 BC.
The preserved ancient sources (see below) are somewhat contradictory and the exact date of Bactrian independence has not been settled. The new kingdom, highly urbanized and considered as one of the richest of the Orient (opulentissimum illud mille urbium Bactrianum imperium "The extremely prosperous Bactrian empire of the thousand cities" Justin, XLI,1The Greeks who caused Bactria to revolt grew so powerful on account of the fertility of the country that they became masters, not only of Ariana, but also of India, as Apollodorus of Artemita says: and more tribes were subdued by them than by Alexander...
during the last two centuries BC and was ruled by more than thirty kings, often conflicting with one another.
A marriage treaty was arranged for the same Demetrius with a daughter of the Seleucid ruler Antiochus III (who had some Persian descent).Chandragupta's grandson Ashoka, who had converted to the Buddhist faith declared in the Edicts of Ashoka, set in stone, some of them written in Greek, Here in the king's domain among the Greeks, the Kambojas, the Nabhakas, the Nabhapamkits, the Bhojas, the Pitinikas, the Andhras and the Palidas, everywhere people are following Beloved-of-the-Gods' instructions in Dharma.Some Greeks (Yavanas) may have played an administrative role in the territories ruled by Ashoka: the Junagadh rock inscription of Rudradaman records that during the rule of Ashoka, a Yavana King/ Governor named Tushaspha was in charge in the area of Girnar, Gujarat, mentioning his role in the construction of a water reservoir.The Datta dynasty and Mitra dynasty soon followed in Mathura.The Indo-Greeks ultimately disappeared as a political entity around 10 AD following the invasions of the Indo-Scythians, although pockets of Greek populations probably remained for several centuries longer under the subsequent rule of the Indo-Parthians and Kushans.