These data reveal a surprising tumour suppressor role for c-Rel in lymphoma development explained by regulation of Bach2 expression, underlining the context-dependent complexity of NF-κB signalling in cancer.
NF-κB activity is required for survival and proliferation.
c-rel knockout mice developed normally with no effects on B-cell maturation but do exhibit some immunological defects, including reduced B-cell proliferation and activation, abnormal germinal centres and reduced number of marginal zone B cells.
Despite this, relatively little is known about the role of c-Rel or other NF-κB subunits in c-Myc-driven lymphomas.
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Here we report the surprising result that c-rel–/– mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lymphoma.However, the contribution of individual NF-κB subunits is generally not known.In particular, whereas NF-κB subunits have been reported to exhibit characteristics of tumour suppressors in vitro, it has not been investigated whether these properties have relevance to lymphoma development in vivo.Working: Screen/Graphics/Touch RIL Data/LTE LED Haptic Feedback Vibration Wi Fi Camera MTP Bluetooth Wi Fi hotspot Builtin ROOT (to enable in Developer Options) Accelerometer GPS Audio Media decoding Charger/Power managment CPU Core handling Sensors Encryption Handle all variant and set custom properties (LCD Density is the priority) Single SIM detection Video Recording Brightness steps Almost working/buggy: LED Colors Hardware H264 acceleration (affect also streaming video playback) Not working/Issues: Kernel doesn't handle Download Mode key combo boot, but Download mode is available with @ Non European users, please test the ROM on your variant (A6020a46, A6020l36, l37) and report back to us with a maximum of informations: - logcat, dmsg, pstore logs - which build you tried - how to reproduce bugs @bittooshubham I can't test it for now.I just received my phone from warranty, and testing the battery performance. When I used A40 on my L36 I was receiving a lot of force close regarding framework and/or and/or settings, and others... Originally Posted by romulocarlos @bittooshubham I can't test it for now.
There are five NF-κB subunits in mammalian cells, Rel A/p65, Rel B, c-Rel, p50/p105 (NF-κB1) and p52/p100 (NF-κB2).