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PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE.BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.INDICATIONS AND USAGE: Karbinal ER (carbinoxamine maleate) Extended-release Oral Suspension is an H1 receptor antagonist indicated for the symptomatic treatment of: Seasonal and perennial allergic rhinitis (1) Vasomotor rhinitis (1) Allergic conjunctivitis due to inhalant allergens and foods (1) Mild, uncomplicated allergic skin manifestations of urticaria and angioedema (1) Dermatographism (1) As therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled (1) Amelioration of the severity of allergic reactions to blood or plasma (1) DOSAGE AND ADMINISTRATION The dosage of Karbinal ER should be individualized based on the severity of the condition and the response of the patient.Start with lower doses and increase as needed and tolerated. Measure Karbinal ER with an accurate milliliter measuring device.Mechanism of Action Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects.Antiserotonin and antihistamine drugs appear to compete with serotonin and histamine, respectively, for receptor sites.
Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA).Diphenhydramine hydrochloride in the injectable form has a rapid onset of action. Management of pruritus: Oral: 25 mg 3-4 times/day Intravenous, intra-arterial, and subcutaneous administration are Adult (usual) Allergy: 25 mg orally at bedtime or 12.5 mg orally before meals and at bedtime. Please review the latest applicable package insert for additional information and possible updates.Diphenhydramine hydrochloride is widely distributed throughout the body, including the CNS. Allergy: 25 mg IV or IM, may repeat within 2 hrs if needed. A local search option of this data can be found here. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE.In laboratory animals, no anticholinergic or alpha1-adrenergic blocking effects were observed.Moreover, no sedative or other central nervous system effects were observed.
Dosing:: one tablet twice daily for adults and children 12 years of age and older (should be taken on an empty stomach).