Relaxed phylogenetics and dating with confidence plos biology dating my guy named chae buchholz

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Relaxed phylogenetics and dating with confidence plos biology

However, this result was unexpected because emergence of Me V was previously considered to have occurred in the prehistoric age [].This age is still within 95% credible intervals of our results.Our results indicate that divergence of Me V from RPV occurred around the 11th to 12th centuries.The population size at that time was sufficient for maintaining Me V.

To avoid weighting specific outbreaks, we also excluded sequences that had been collected at the same time and place and that were genetically similar to each other.Alternatively, a common ancestor of Me V and RPV may have caused zoonosis in the past; the archaeovirus can infect both humans and cattle.Even if the earliest urban civilizations in ancient Middle Eastern river valleys (around 3000 to 2500 BCE) were infected by an ancestor of the current Me V, the virus probably had different characteristics from the current Me V.Runs were carried out with chain lengths of 100 million and the assumption of an 'exponential population growth' using a 'relaxed (uncorrelated lognormal) molecular clocks' [). Analyses for the H gene yielded similar results; the TMRCA of the current Me V was 1916.1074 was estimated to be the date of divergence between Me V and RPV.

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